Article 4: Protocol for the Management of Keloid Scars
Insights into the Management of Keloid Scars: A Survey-Based Protocol
Kenneth B. Hughes, M.D.
In the broad array of literature as it relates to keloid treatment, there is a global absence of definitive protocols in the management of keloid scars.
The goal of this project was to find some common ground in treatment regimens among plastic surgeons and to determine how our treatment protocol compares with those of other plastic surgeons. To this end, a web-based survey was designed and over 700 random emails were sent to plastic surgeons worldwide, with 54 completing the survey. These results were then tabulated and the more common regimens identified.
The results of the survey, while useful in identifying common regimens and helping to substantiate the validity of our protocol, underscore the need for randomized, controlled trials to bring about more consistency in regimens used.
Keloids arise as an aberrant tissue response to cutaneous insult characterized by the production of excessive fibrous tissue. Keloids extend beyond the original boundaries of tissue injury and may appear months to years after injury. They occur with equal frequency in males and females and occur most commonly in younger people.
Keloids have a predilection for the earlobes, chest, back, neck, and shoulders. Keloids tend to afflict those people that are more pigmented, with blacks being the most susceptible. Keloids may be symptomatic; commonly causing itching, tenderness, and pain. The etiology of keloids is unknown. Some have demonstrated that increased extracellular matrix production is characteristic. 1-4 Keloids remain difficult to treat under even the most optimal of conditions, and they frequently recur.
An array of adjunctive therapies including silicone gel sheeting, pressure garments, intralesional steroids, and radiotherapy have been employed with variable success.
Several randomized, controlled trials have confirmed the validity and effectiveness of silicone sheeting. 5-11 Though effective, the silicone material be worn continuously for months at a time to prevent rebound hypertrophy. 12
Pressure therapy involves the exertion of at least 24 mmHg to exceed the inherent capillary pressure. 13,14 Much like silicone materials, pressure garments should be worn 18 to 24 hours a day for several months. 15-18 Surgery in conjunction with pressure therapy has produced success rates of up to 90 percent. 19-23
Steroids have been demonstrated to soften the contours and reduce the bulk of keloids. 24-28 Response rates vary from 50 to 100 percent, with recurrence rates of up to 50 to 80 percent. 24-28 Steroids purportedly decrease collagen synthesis by increasing metalloproteinase activity. 29-34 The optimal number of injections to be performed and the amounts injected to produce an optimal response are largely up for speculation.
Radiotherapy has been employed as both adjunctive and primary treatment. Radiation therapy is presumed to destroy the proliferating fibroblasts, resulting in diminished collagen production. 35 Radiation treatments are typically administered over five to six sessions in the early postoperative period. 36, 37 The combination of surgery and perioperative radiation therapy reduces recurrence to 10 percent according to some authors. 35 Historically, radiation therapy has been reserved for abnormal scars resistant to other treatments due to the presumed risks posed by radiation.
Excision and Intralesional Steroids
Though all of the modalities presented thus far have roles to play in keloid management, local excision in combination with intralesional kenalog has long been the definitive treatment for keloids. However, there is lack of a standardized protocol (including specific steroid, strength, number, and frequency of doses to be administered) in the published literature. 38
To undertake this task of searching for a treatment protocol, a random compilation of board certified plastic surgeons was made comprising over 700 names. Next all of these selectees were emailed a letter asking for participation in filling out a web-based survey. Ultimately, 54 respondents filled out the survey.
Participants were queried on steroid preference, concentration and volume injected, number of treatments, frequencies, and the temporal relationship of those injections to excision. Finally, those surveyed were asked to provide additional therapies they found useful in treating keloids.
The results were then tabulated and expressed as percentages. Only the most common responses have been tabulated.
Q month x 3 50%
Q 6 weeks x 3 25%
Q month x 3 39%
Q 6 weeks x 3 32%
Postoperative Adjunctive Management
Silicone Gel Sheeting
22% as primary form of treatment after excision
46% for refractory keloids
Table 1 illustrates that Triamcinolone (kenalog ® )appears to be the overwhelming favorite for steroid injection. Although the majority of the respondents used 40 mg ml concentrations, many of these were diluted 2 to 1. After accounting for dilution, relatively equal numbers used each of the concentrations of kenalog.
Table 2 reveals that all of the plastic surgeons surveyed practice excision, which is what one expects when referred to a surgeon for treatment of a keloid. One also notices that the majority of surgeons injected 1ml and that the majority administer perioperative steroids. As far as dosing intervals go, q month dosing for a total of 3 treatments was the most common preop and post op regimen, with q6 week dosing for 3 doses being the second most common.
While excision and intralesional kenalog® constitute the most common treatment algorithm, it was interesting to note that (see Table 3) 22% used radiation as a primary form of treatment following excision, and that almost ½ used radiation at some point in their treatment algorithm. Silicone gel sheeting (26%), compression garments (22%), and cordran tape (17%) constituted the majority of the other adjunctive therapies.
Therefore, if one were trying to define the most common algorithm, it would consist of the following:
1) Excise the keloid, injecting 1 ml of 10, 20, or 40 mg/dl kenalog at the time of surgery
2) Inject 1 ml of 10, 20, or 40 mg/dl kenalog into the keloid postoperatively every month for a total of 3 doses
These findings are largely supportive of and consistent with the protocol presented by the authors:
1 cc of Triamcinolone 10mg/ml (kenalog 10®) is injected in the lesion (in smaller lesions fluid is injected until blanching is obtained). After a waiting period of 2-3 weeks, a full excision of the lesion is performed, while achieving good hemostasis and utilizing non-absorbable suture material for closure. At postoperative day 7, the suture material is removed and 1 cc of kenalog® 10 injected into the surgical scar. This is followed by 2 more injections of the steroid every 4 weeks.
Excision after 2 weeks
Injection #2 at 1 week post op
Injection # 3
at 4 weeks,
Injection #4 at 8 weeks
Hopefully, the findings articulated in this paper will be useful to plastic surgeons managing keloid scars, particularly those physicians just beginning a practice and physicians in training. The paper also highlights the overwhelming need for prospective randomized trials to examine such protocols and their validity in the management of keloids. However, the results obtained within this paper do shed light upon the current thinking and management tactics of practicing plastic surgeons worldwide.
Article 1: The Role of Telemedicine in the Management of the Cosmetic Surgery Patient
Article 2: Breast Implant Reconstruction after Radiation
Article 3: Breast Reconstruction after Mastectomy
Article 4: Protocol for the Management of Keloid Scars
Article 5: Melanoma and the Role of Sentinel Lymph Node Biopsy
Article 6: Desmoid tumors of Bilateral Breasts
Article 7: The Role of the Paramedian Incision
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